You might also like these other newsletters: Please enter a valid email address Sign up Oops! Please enter a valid email address Oops! Please select a newsletter Doctors can prescribe a variety of treatments to ease pain and discomfort in this sensitive area. Corbis; Getty Images; iStock Photo Many conditions, including hemorrhoids and anal fissures, result in irritation and discomfort in the anal region. Fortunately, there are simple ways to ease anal discomfort and get relief.